Oxycodone vs hydrocodone vs codeine. Common Questions and Answers about Oxycodone vs hydrocodone vs codeine. vicodin. hydrocodone (schedule III, in bulk formulations. PHOENIX, Arizona — Hydrocodone/acetaminophen (Vicodin, AbbVie) was not superior to codeine/acetaminophen (Tylenol 3, McNeil) in acute pain relief reported by. Codeine and hydrocodone are two commonly prescribed pain medications. Understand the important differences and similarities in these two medications. Which is better: Tylenol with Codeine 3 or Vicodin? More patient posts reported that Vicodin helped them when used for Pain Can anyone tell me the difference between tylenol 3 and hydrocodone, I understand the hydrocodone is a synthetic of codeine, but as far a strength of tylenol 3 vs one. One is called hydrocodone with tylenol & the other is codeine with. Vicodin (Hydrocodone with Tylenol), Tylenol 3, and others like it can cause headaches as well Vicodin is six times stronger than Codeine. But experts recommend generic codeine for its long track record of effectiveness, safety, flexibility and cost. More 1. Ann Emerg Med. 1991 Oct;20(10):1100-3. Hydrocodone versus codeine in acute musculoskeletal pain. Turturro MA(1), Paris PM, Yealy DM, Menegazzi JJ. Hydrocodone and codeine are NOT the same chemical compound; they're two different drugs. Codeine is the 3-methylether of morphine.